EP2377538A1 — Aqueous oral preparation of stable amlodipine

USPTO Abstract

The present invention aims to provide a stable aqueous oral preparation (liquid or jelly preparation) of amlosipine. The object aqueous oral preparation (jelly preparation) of amlodipine, which is stable and highly rapidly disintegratable, could be produced by using an anionic surfactant having a sulfuric acid group or a sulfonic acid group as a stabilizer in an aqueous solution of amlodipine, preparing a liquid stable in the range of pH 5 - 7 as the liquid property, and adding and mixing a gelling agent, a fine powder solid and a gelling regulator. As a result, a novel oral preparation (liquid or jelly preparation) easy to take for older patients, who have declined swallowing function and face difficulty in taking tablets, can be provided.