EP2314714A1 — Disease susceptibility

USPTO Abstract

The invention provides a method of assessing the susceptibility of a subject to an anxiety disorder or depression, the method comprising determining whether the subject has a haplotype comprising rs3216799, rs6814934, rs765e048, rs2070950 and rs2070951 with respective alleles '+CT', 'C', 'T', 'C' and 'C'. The invention provides a kit of parts or solid substrate for use in assessing the susceptibility of a subject to an anxiety disorder or depression, the kit comprising or the solid substrate having attached thereto one or more nucleic acid molecules that hybridise selectively to a genomic region encompassing any two or more SNPs selected from the group consisting of r53218799, rs6814934, rs7658048, rs2070a50 and rs2070951, and/or that hybridise selectively to a genomic region encompassing two or more polymorphic sites in linkage disequilibrium with any one or more SNPs selected from the group consisting of rs3216799, rs6814934, rs7658048, rs2070950 and rs2070951.