EP2238979A1 — Active pharmaceutical ingredient adsorbed on solid support

USPTO Abstract

Dosage forms comprising tadalafil adsorbed on a particulate carrier. Furthermore it is disclosed an adsorbate comprising tadalafil adsorbed on a particulate carrier. The present invention also refers to a process for the preparation of the adsorbate comprising the steps of (a) providing an API being practically insoluble in water; (b) providing solid support carrier particles; (c) placing the API and the carrier particles into a predetermined solvent which, allows adsorption of the API on the surface of carrier particles but gives substantially no precipitate, and (d) removing the solvent to form an API-carrier adsorbate. Furthermore the invention relates to a process for the preparation of the dosage form, as well as to the use of the adsorbate for the preparation of the dosage form. Moreover it relates to the dosage form for use in the treatment of erectile dysfunction, hypercholesterolemia, human immunodeficiency virus (HIV) infections and/or Acquired Immune Deficiency Syndrome (AIDS).