EP2190433A2 — Therapy for complications of diabetes

USPTO Abstract

A selective ETA receptor antagonist for use in a method for enhancing glycemic control and/or insulin sensitivity in a human subject having diabetic nephropathy and/or metabolic syndrome is disclosed. A selective ETA receptor antagonist for use in treating a complex of comorbidities in an elderly diabetic human subject, wherein the selective ETA receptor antagonist is for administration in combination or as adjunctive therapy with (a) at least one additional agent that is (i) other than a selective ETA receptor antagonist and (ii) effective in treatment of diabetes and/or at least one of said comorbidities other than hypertension, and optionally (b) at least one antihypertensive other than a selective ETA receptor antagonist is disclosed. Further, a therapeutic combination comprising a selective ETA receptor antagonist and at least one antidiabetic, anti-obesity or antidyslipidemic agent other than a selective ETA receptor antagonist is disclosed.