EP Patent

EP2173729A1 — Process for making substituted 2-amino-thiazolones

Assigned to Amgen Inc · Expires 2010-04-14 · 16y expired

What this patent protects

ABSTRACT The present invention relates to methods of making compounds that inhibit 11- -hydroxysteroid dehydrogenase type 1 enzyme (11- HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkyla…

USPTO Abstract

ABSTRACT The present invention relates to methods of making compounds that inhibit 11- -hydroxysteroid dehydrogenase type 1 enzyme (11- HSD1). One method comprises (a) contacting a compound of formula (II) sequentially with a chiral base in the presence of an amine, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I). wherein Z, R1, R2, and R3 are defined herein.

Drugs covered by this patent

Patent Metadata

Patent number
EP2173729A1
Jurisdiction
EP
Classification
—
Expires
2010-04-14
Drug substance claim
No
Drug product claim
No
Assignee
Amgen Inc
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.