EP2098233A1 — Skin adhesive preparation comprising stabilized donepezil

USPTO Abstract

[Object] A donepezil-containing adhesive preparation is provided whereby formation of donepezil-related substances in a pressure-sensitive adhesive layer is inhibited. [Solution] A stabilizer containing one or more species selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, cysteine, acetylcysteine, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3',5'-di-t-butyl-4'-hydroxyphenyl)propionic acid]pentaerythritol, 3-mercapto-1,2-propanediol, tocopherol acetate, rutin, quercetin, hydroquinone, a metal salt of hydroxymethanesulfinic acid, a metal metabisulfite salt, a metal sulfite salt and a metal thiosulfate salt, is blended in a donepezil-containing pressure-sensitive adhesive layer provided on at least one side of a support.