EP Patent

EP2066667B1 — Process for the preparation of pyrido[2,1-a]isoquinoline derivatives comprising optical resolution of an enamine

Assigned to F Hoffmann La Roche AG · Expires 2011-08-31 · 15y expired

What this patent protects

This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of…

USPTO Abstract

This invention relates to a process for the preparation of pyrido[2,1-a]isoquinoline derivatives of the formula wherein R1, R2, R3 and R4 are defined in the specification, comprising the optical resolution of an enamine of the formula wherein R1 is lower alkyl, in the presence of an optical active resolving agent to form an (S)-enamine salt of the formula wherein RCO2- is the conjugate base of the resolving agent.

Drugs covered by this patent

Patent Metadata

Patent number
EP2066667B1
Jurisdiction
EP
Classification
—
Expires
2011-08-31
Drug substance claim
No
Drug product claim
No
Assignee
F Hoffmann La Roche AG
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

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