EP2019105A1 — Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
Assigned to Siegfried AG · Expires 2009-01-28 · 17y expired
What this patent protects
The present invention relates to a process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives of general formula (I) a or b wherein A is -C(O)-, -C(S)-, -C(=CH 2 )-, or -CHA 1 -, R 1 is hydrocarbyl or substituted hydrocarbyl, R 2 is hyd…
USPTO Abstract
The present invention relates to a process for the preparation of quaternary N-alkyl morphin or morphinan alkaloid derivatives of general formula (I) a or b wherein A is -C(O)-, -C(S)-, -C(=CH 2 )-, or -CHA 1 -, R 1 is hydrocarbyl or substituted hydrocarbyl, R 2 is hydrocarbyl or substituted hydrocarbyl, preferably selected from substituted or unsubstituted, saturated or unsaturated compounds of from 1 to 8 carbons; X - is an anion, Y is hydrogen, hydroxy, alkoxy, or acyloxy. This is achieved by using a nucleophilic nitrogen, phosphor or sulfur, containing base in the reaction mixture.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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