EP Patent

EP1999108A1 — Preparation of (r)-3-aminopiperidine dihydrochloride

Assigned to Takeda Pharmaceutical Co Ltd · Expires 2008-12-10 · 17y expired

What this patent protects

Described herein are methods for making chiral derivatives of 3-aminopiperidine, including the production of such derivatives in quantities exceeding 1 kilogram. The chiral 3-aminopiperidine derivatives include (R) -3-aminopiperidine derivatives which may be used to synthesize in…

USPTO Abstract

Described herein are methods for making chiral derivatives of 3-aminopiperidine, including the production of such derivatives in quantities exceeding 1 kilogram. The chiral 3-aminopiperidine derivatives include (R) -3-aminopiperidine derivatives which may be used to synthesize inhibitors of Dipeptidyl Peptidase IV. (R) -3-Aminopiperidine dihydrochloride is prepared by reducing (R) -3-aminopiperidin-2-one hydrochloride with lithium aluminum hydride. The preparation of (R) -3-aminopiperidin-2-one hydrochloride starting from (R) -methyl-2, 5-diaminopentanoate dihydrochloride or (R) -2, 5-diaminopentanoic acid hydrochloride is also described.

Drugs covered by this patent

Patent Metadata

Patent number
EP1999108A1
Jurisdiction
EP
Classification
—
Expires
2008-12-10
Drug substance claim
No
Drug product claim
No
Assignee
Takeda Pharmaceutical Co Ltd
Source
FDA Orange Book + USPTO grounding via Google Patents

Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.

Track this patent

Get a daily-checked alert when vulnerability score, expiry, classification, or assignee changes. Email, Slack, or Teams delivery. Pro: 50 watches, Free: 3.