EP1914235A1 — Chiral tetra-hydro beta-carboline derivatives and applications thereof as antiparasitic compounds

USPTO Abstract

The invention relates to the use of chiral tetra-hydro β-carboline derivatives of formula (I) for the preparation of pharmaceutical composition for the prevention and/or the treatment of parasitic diseases involving parasites having a phosphodiesterase activity: or a pharmaceutically acceptable salt thereof, in which: - R 1 and R 2 , identical or different, represent a hydrogen atom or a fluorine atom; - k is an integer equal to 0 or 1; - R 3 is selected from the group consisting of: ■ a phenyl ring optionally substituted ■ a 3'-N-pyridine ring optionally substituted - R 4 is a group selected in the group consisting of the following groups: -NH-A-R 5 , -NHC(O)-R 5 and the groups of formulas (II-a) to (II-c) below: The invention also relates to some new chiral tetra-hydro β-carboline derivatives.