EP1857548A1 — Means and method for inducing exon-skipping
Assigned to Leids Universitair Medisch Centrum LUMC · Expires 2007-11-21 · 18y expired
What this patent protects
In the present invention means and method are provided for optimising exon-skipping using exon-internal AON. We show that skipping efficiencies are improved by targeting putative splicing regulatory sequences (ESEs) within an exon. Such double targeting may be particularly useful…
USPTO Abstract
In the present invention means and method are provided for optimising exon-skipping using exon-internal AON. We show that skipping efficiencies are improved by targeting putative splicing regulatory sequences (ESEs) within an exon. Such double targeting may be particularly useful for exons with which efficient skipping was difficult to obtain prior to the invention.
Drugs covered by this patent
- Amondys 45 (CASIMERSEN) · Sarepta
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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