EP1721889A1 — Process for the preparation of phenethylamine derivatives
Assigned to Dishman Carbogen Amcis Ltd · Expires 2006-11-15 · 20y expired
What this patent protects
The present invention relates to a process of preparing venlafaxine and derivatives thereof comprising reducing the corresponding β-hydroxynitriles using a reducing borohydride agent selected from tetraalkylammonium borohydride and aralkyltrialkylammonium borohydride. According t…
USPTO Abstract
The present invention relates to a process of preparing venlafaxine and derivatives thereof comprising reducing the corresponding β-hydroxynitriles using a reducing borohydride agent selected from tetraalkylammonium borohydride and aralkyltrialkylammonium borohydride. According to the present process, said β-hydroxynitrile can be prepared by condensating a phenylacetonitrile and cyclohexanone using a phase transfer catalyst and a base at a temperature of between 10-25 °C. Advantageously, in the present method, the use of hazardous catalysts and reducing agents is avoided and unexpectedly low amounts of reducing borohydride agent can be used.
Drugs covered by this patent
- Pristiq (Desvenlafaxine Succinate) · Pfizer
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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