EP1670785B1 — Salts and polymorphs of a pyrrole-substituted indolinone compound
Assigned to Pharmacia and Upjohn Co LLC · Expires 2010-07-07 · 16y expired
What this patent protects
The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H--indol-3-ylidene)methyl]-N-[(2)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3--yarboxamide,shown in structural formula (1) such as maleate salts, and to crystalline polymorphs o…
USPTO Abstract
The invention relates to non-hygroscopic salts of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H--indol-3-ylidene)methyl]-N-[(2)-2-hydroxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3--yarboxamide,shown in structural formula (1) such as maleate salts, and to crystalline polymorphs of these salts. The invention further relates to pharmaceutical compositions of 5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3--ylidene)methyl]-N-[(2S)-2-hyd carboxamide salts, and meth roxy-3-morpholin-4-ylpropyl]-2,4-dimethyl-1 H-pyrrole-3- ds of treating disorders such as cancer using such compositions.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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