EP1661889A4 — Chemokine receptor antagonist and medical use thereof

USPTO Abstract

A compound of the general formula: (I) (wherein the characters are as defined in the description), or its salt or N-oxide compound, or a solvate thereof, or a prodrug thereof, and medical use of these. The compound of the general formula (I) is one having chemokine receptor (especially CCR4 and/or CCR5, etc.) antagonism, and is useful for the prevention and/or treatment of diseases associated with chemokine receptor, for example, inflammatory/allergic diseases [systemic inflammatory response syndrome (SIRS), anaphylaxis, anaphylactic reaction, allergic angiitis, organ transplant rejection reaction, hepatitis, nephritis, nephropathy, pancreatitis, rhinitis, arthritis, inflammatory ocular disease, inflammatory bowel disease, cerebral/circulatory disease, respiratory disease, dermal disease, autoimmune disease, etc.], infectious diseases [viral diseases (HIV infection, AIDS, SARS, etc.), etc.], etc.