EP1630169A2 — Intermediates for LHRH antagonist synthesis, process for their production, and process for LHRH antagonist production
Assigned to Polypeptide Laboratories AS · Expires 2006-03-01 · 20y expired
What this patent protects
The invention relates to a process for preparing a tripeptide, including a salt thereof, of the formula (IX) Boc-D-2Nal-D-4CIPhe-D-3Pal-OH (IX) comprising the following consecutive steps: (a) Reacting Boc-D-4ClPhe-OH with HONSu to form Boc-D-4ClPhe-OSu (VII); (b) Reactin…
USPTO Abstract
The invention relates to a process for preparing a tripeptide, including a salt thereof, of the formula (IX) Boc-D-2Nal-D-4CIPhe-D-3Pal-OH (IX) comprising the following consecutive steps: (a) Reacting Boc-D-4ClPhe-OH with HONSu to form Boc-D-4ClPhe-OSu (VII); (b) Reacting Boc-D-4ClPhe-OSu (VII) with H-D-3Pal-OH to form Boc-D-4ClPhe-D-3Pal-OH (VIII); (c) Reacting Boc-D-4ClPhe-D-3Pal-OH (VIII) with Boc-D-2Nal-OSu prepared by reacting Boc-D-2Nal-OH with HONSu to form Boc-D-2Nal-D-4ClPhe-D-3Pal-OH (IX).
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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