EP1566379A4 — QUINOLINE AND QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FLT3 AND MEDICAL COMPOSITIONS CONTAINING SAME

USPTO Abstract

It is intended to provide compounds and drugs efficacious against diseases which can be effectively treated by inhibiting autophosphorylation of FMS-like tyrosine kinase 3 (Flt3). Namely, a medicinal composition to be used in preventing or treating diseases which can be effectively treated or prevented by inhibiting autophosphorylation of Flt3, comprising a compound represented by the following general formula (I) or pharmaceutically acceptable salts thereof or solvates of the same: (I) wherein X represents CH or N; Z represents O or S; R1, R2 and R3 represent each H, OH or optionally substituted alkoxy; R4 represents H; R5, R6, R7 and R8 represent each H, Hal, alkyl, etc.; and R9 represents alkyl, etc. substituted by t-butyl, etc.