EP1566379A1 — QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF Flt3 AND MEDICINAL COMPOSITIONS CONTAINING THE SAME

USPTO Abstract

An objective of the present invention is to provide compounds and pharmaceticals useful for the treatment of disease where the inhibition of autophosphorylation of FMS-like tyrosine kinase 3(Flt3) is therapeutically effective. The present invention relates to a pharmaceutical composition for use in the treatment or prevention of diseases where the inhibition of autophosphorylation of Flt3 therapeutically or prophylactically effective, which comprises a compound represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: <CHEM> wherein X represents CH or N; Z represents O or S; R<1>, R<2>, and R<3> represent H, OH, or optionally substituted alkoxy; R<4> represents H; R<5>, R<6>, R<7>, and R<8> represent H, Hal, alkyl or the like; and R<9> represents, e.g., alkyl substituted by t-butyl or the like.