EP1550668A1 — Pyrazole derivative, medicinal composition containing the same, medicinal use thereof and intermediate in producing the same

USPTO Abstract

The present invention provides pyrazole derivatives represented by the general formula: wherein R 1 represents H, an optionally substituted C 1-6 alkyl group etc. ; one of Q and T represents a group selected from the following goups: , and the other represents -(CH 2 ) n -Ar wherein Ar represents an optionally substituted C 6-10 aryl group or an optionally substituted C 1-9 heteroaryl group; and n represents an integral number from 0 to 2, an optionally substituted C 1-6 alkoxyl group, an optionally substituted amino group, an optionally substituted C 2-9 heterocycloalkyl group or an optionally substituted heterocycle-fused phenyl group; R represents an optionally substituted C 3-8 cycloalkyl group, an optionally substituted C 6-10 aryl group etc., pharmaceutically acceptable salts thereof or prodrugs thereof, which exhibit an excellent inhibitory activity in human 1,5-anhydroglucitol/fructose/mannose transporter and are useful as agents for the prevention, inhibition of progression or treatment of a disease associated with the excess uptake of at least a kind of carbohydrates selected from glucose, fructose and mannose or a disease associated with hyperglycemia (e.g., diabetic complications, diabetes, etc.), and pharmaceutical compositions comprising the same, pharmaceutical uses thereof, and intermediates for production thereof.