EP1541558A1 — Heterocyclic compound having hiv integrase inhibitory activity

USPTO Abstract

A heterocyclic compound of the formula (I): wherein B 1 is -C(R 2 )= or -N=; R 1 ' is H, etc.; one of R 1 and R 2 is -Z 1 -Z 2 -Z 3 -R 5 wherein Z 1 and Z 3 are independently single bond, optionally substituted alkylene, etc.; Z 2 is single bond, optionally substituted alkylene, etc.; R 5 is optionally substituted aryl, optionally substituted heteroaryl, etc., and the other of R 1 and R 2 is H; -A 1 - is -C(-Y)=C(-R A )-C(-R 3 )=C(-R 4 )-, etc. wherein Y is OH, etc.; R A is -COR 7 wherein R 7 is OH, etc.; one of R 3 and R 4 is carboxy, etc., and the other of R 1 and R 2 is H, etc, a prodrug thereof, a pharmaceutically acceptable salt thereof, and a solvate thereof, having an antiviral activity, more particularly, an inhibitory activity against HIV integrase, and a pharmaceutical composition containing the same, especially an anti-HIV drug.