EP1479666A1 — Ester compound and medicinal use thereof

USPTO Abstract

A novel therapeutic agent for hyperlipidemia, which is an ester compound represented by the formula (1") (wherein    R 1 and R 2 are each hydrogen atom or optionally substituted aryl, etc.;    X is -COO- or -CON(R 10 )-;    R 3 and R 4 are each hydrogen atom, C 1 -C 6 alkyl or C 1 -C 6 alkoxy, etc.;    R 5 , R 6 and R 7 are each hydrogen atom, C 1 -C 6 alkyl or C 1 -C 6 alkoxy, etc.;    R 8 and R 9 are each independently hydrogen atom, C 1 -C 6 alkyl, -CON(R 18 )(R 19 ) or -COO(R 20 ), etc.;    ring A, ring B and ring C are each independently aryl or heterocycle residue, etc.;    Alk 1 and Alk 2 are each independently alkanediyl, etc.;    l and m are each an integer of 0 or 1 to 3) or a prodrug thereof, or a pharmaceutically acceptable salt of either. The therapeutic agent selectively inhibits MTP in the small intestine, thus causes no such side effect as a fatty liver.