EP1411046A1 — QUINOLINE DERIVATIVE AND QUINAZOLINE DERIVATIVE INHIBITING SELF−PHOSPHORYLATION OF HEPATOCYTUS PROLIFERATOR RECEPTOR, AND MEDICINAL COMPOSITION CONTAINING THE SAME

USPTO Abstract

An objective of the present invention is to provide compounds having potent antitumor activity. The compounds of the present invention are represented by formula (I) or a pharmaceutically acceptable salt or solvate thereof: wherein X = CH or N; Z = O or S; L = O or S; M = CR 10 R 11 , wherein R 10 and R 11 = H, alkyl, or alkoxy, NR 12 wherein R 12 = H or alkyl; R 1 , R 2 , and R 3 = H or optionally substituted alkoxy; R 4 = H; R 5-8 = H, halogen, alkoxy or the like; and R 9 = alkyl optionally substituted by -R 14 , -T-R 15 , or -NR 16 R 17 wherein T = O, S, or NH; R 14 = an optionally substituted carbocyclic or heterocyclic ring; and R 15-17 = alkyl or an optionally substituted carbocyclic or heterocyclic ring, or -NR 18 R 19 wherein R 18 and R 19 = H, optionally substituted alkyl, or an optionally substituted carbocylic or heterocyclic ring, or optionally substituted carbocyclic or heterocyclic ring.