EP1380562A1 — Carboxylic acid derivative and salt thereof

USPTO Abstract

The present invention provides a novel carboxylic acid compound, a salt thereof or a hydrate of them useful as an insulin sensitizer, and a medicament comprising the compound as an active ingredient. That is, the present invention provides a carboxylic acid compound represented by the following formula, a salt thereof, an ester thereof or a hydrate of them. <CHEM> Wherein R<1> represents a hydrogen atom, hydroxyl group, halogen, carboxyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents; L represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; M represents a single bond, or a C1-6 alkylene group, a C2-6 alkenylene group or a C2-6 alkynylene group, each of which may have one or more substituents; T represents a single bond, or a C1-3 alkylene group, a C2-3 alkenylene group or a C2-3 alkynylene group, each of which may have one or more substituents; W represents a carboxyl group; - - - represents a single bond etc. ; X represents a single bond, oxygen atom, a group represented by -NR<X1>CQ<1>O- (wherein Q<1> represents an oxygen atom or sulfur atom; and R<X1> represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents), -OCQ<1>NR<X1>- (wherein Q<1> and R<X1> are as defined above), -CQ<1>NR<x1>O- (wherein Q<1> and R<X1> are as def ined above), ONR<X1>CQ<1>- (wherein Q<1> and R<X1> are as defined above), - Q<2>SO2- (wherein Q<2> is an oxygen atom or -NR<X10>- (wherein R<X10> represents a hydrogen atom, formyl group, or a C1-6 alkyl group etc., each of which may have one or more substituents)) or -SO2Q<2>- (wherein Q<2> is as defined above), (wherein, provided that R<X2> and R<X3>, and/or R<X4> and R<X5> may together form a ring, Q<3> and Q<4> are the same as or different from each other and each represents an oxygen atom, (O)S(O) or NR<X10> (wherein NR<X10> is as defined above)); Y represents a 5- to 14-membered aromatic group etc., which may have one or more substituents and one or more hetero atoms; and the ring Z represents a 5-to 14-membered aromatic group which may have 0 to 4 substituents and one or more hetero atoms, and wherein part of the ring may be saturated.