EP1340748A1 — Quinazoline derivatives and drugs

USPTO Abstract

The invention provides an excellent novel analgesic which acts on a nociceptin receptor to exhibit a wide range of the analgesic effect for example on a chronic pain as well as an allodynia accompanied with a herpes zoster. The invention relates to a nociceptin receptor agonist comprising as an active ingredient a compound represented by Formula (I) or a salt thereof:    wherein R 1 represents a hydrogen atom or alkyl; A 1 and A 2 are the same or different and each represents a single bond or a divalent aliphatic hydrocarbon group; Q represents a single bond, cycloalkylene group, phenylene group or a divalent heterocyclic group; R 2A and R 2B are the same or different and each represents a hydrogen atom or alkyl; R 3 represents an optionally substituted phenyl group or heterocyclic group; R 4 and R 5 are the same or different and each represents a hydrogen atom, alkyl, alkoxy, aralkyloxy, halogen, nitro, hydroxy, alkoxycarbonyl, -NR 6 R 7 and the like.