EP1322628A2 — Substituted urea neuropeptide y y5 receptor antagonists

USPTO Abstract

Compounds represented by structural formula (I) including its N-oxides wherein Y is (a) or (b); R1 is H or (C¿1?-C6)alkyl; R?2¿ is H,(C¿1?-C6)alkyl,(C3-C9)cycloalkyl or (C3-C7)cycloalkyl(C1-C6)alkyl; R?3¿ is (c), (d), (e), (f), (g), (h) or (i); R4 is 1-3 substituents independently selected from the group consisting of H, -OH, halogen, haloalkyl,(C¿1?-C6) alkyl, (C3-C7) cycloalkyl, (C3-C7) cycloalkyl (C1-C6) alkyl, -CN, -O(C1-C6) alkyl, -O(C3-C7) cycloalkyl, -O(C1-C6) alkyl (C3-C7) cycloalkyl, -S(C1-C6) alkyl, -S(C3-C7) cycloalkyl, -S(C1-C6) alkyl(C3-C7) cycloalkyl, -NH2, -NR?9R10, -NO¿2, -CONH2, -CONR?9R10 and NR2COR10¿; or where applicable, a geometric or optical isomer or a racemic mixture thereof, are claimed, as well as additional novel compounds; also claimed are pharmaceutical compositions and methods of using the aforesaid compounds in the treatment of obesity, eating disorders such as hyperphagia and diabetes.