EP1275381A1 — Time-release coated solid compositions for oral administration

USPTO Abstract

The present invention relates to a timed-release compression-coated said composition for oral administration, said composition being a hydrgel-forming compression-coated solid preparation comprising a core tablet comprising a drug and an outer layer comprising a hydrogel-forming polymer substance and a hydrophilic base, characterized in that (1) said core tablet comprising a drug and a freely erodible filler, (2) said core tablet is capable of approximately 40 to approximately 90% erosion; and (3) said outer layer substantially does not comprise the same drug with said drug. By releasing a drug after a specific lag time, it becomes possible to effectively deliver a drug to a specific site in the digestive tract. It is therefore useful as presented as a timed-release solid composition for oral administration of a drug that is to be effectively delivered in high concentrations to the afflicted site in the lower digestive tract, a drug that is to be effectively absorbed in the lower digestive tract, a drug that is effective for chronopharmacotherapy, etc.