EP1266659A1 — Pyridoxal in combination with serotonin re-uptake inhibitor for the treatment of hot flushes

USPTO Abstract

The present invention is concerned with formulations for use in a method of suppressing hot flushes, especially hot flushes in hypo-estrogenic females and androgen-deprived males. More particularly the invention relates to a pharmaceutical formulation for use in a method of suppressing hot flushes, said method comprising the administration of the formulation so as to provide on a daily basis a combination of: a. serotonin re-uptake inhibitor in an amount which is equivalent to less than 100 mg trazodone and b. vitamin B6 component, in an amount effective to to reduce the incidence and/or intensity of hot flushes Another aspect of the invention relates to pharmaceutical formulations comprising a combination of a. serotonin re-uptake inhibitor in an amount which is equivalent to 0.6 to 45 mg, preferably 0.6 to 24 mg trazodone and b. 0.005 to 5 mmoles of vitamin B6 component, and additionally comprising pharmaceutically acceptable excipient.