EP1184376B1 — Novel heterocyclic carboxamide derivatives

USPTO Abstract

A nitrogen-containing six-membered heterocyclic compound having substituents -X-A-R<3>, -N(R<1>)-(Ph substituted by R<2>), and -CONH2, or a salt thereof. (The symbols have the following meanings. A: a lower alkylene which may have substituent(s), an arylene which may have substituent(s), a heteroarylene which may have substituent(s), or a cycloalkylene which may have substituent(s); X: NR<4>, CONR<4>, NR<4>CO, O, or S; R<1>, R<4>: H, a lower alkyl, -CO-lower alkyl, or -SO2-lower alkyl; R<2>: H, a lower alkyl, a halogen, a lower alkyl substituted by halogen(s), -O-lower alkyl, -S-lower alkyl, -O-aryl, -O-lower alkylene-aryl, -S-lower alkylene-aryl, nitro, or cyano group; R<3>: -CO2H, -CO2-lower alkyl, -lower alkylene-CO2H, -lower alylene-CO2-lower alkyl, -CONHOH, -CONHO-lower alkyl, -lower alkylene-CONHOH, -lower alkylene-CONHO-lower alkyl, -NH2, -(NH2 in a prodrug form), -lower alkylene-NH2, or -lower alkylene-(NH2 in a prodrug form))