EP1184376A1 — Novel heterocyclic carboxamide derivatives

USPTO Abstract

A nitrogen-containing six-membered heterocyclic compound having substituents -X-A-R 3 , -N(R 1 )-(Ph substituted by R 2 ), and -CONH 2 , or a salt thereof. (The symbols have the following meanings. A: a lower alkylene which may have substituent(s), an arylene which may have substituent(s), a heteroarylene which may have substituent(s), or a cycloalkylene which may have substituent(s); X: NR 4 , CONR 4 , NR 4 CO, O, or S; R 1 , R 4 : H, a lower alkyl, -CO-lower alkyl, or -SO 2 -lower alkyl; R 2 : H, a lower alkyl, a halogen, a lower alkyl substituted by halogen(s), -O-lower alkyl, -S-lower alkyl, -O-aryl, -O-lower alkylene-aryl, -S-lower alkylene-aryl, nitro, or cyano group; R 3 : -CO 2 H, -CO 2 -lower alkyl, -lower alkylene-CO 2 H, -lower alylene-CO 2 -lower alkyl, -CONHOH, -CONHO-lower alkyl, -lower alkylene-CONHOH, -lower alkylene-CONHO-lower alkyl, -NH 2 , -(NH 2 in a prodrug form), -lower alkylene-NH 2 , or -lower alkylene-(NH 2 in a prodrug form))