EP1117396A1 — A method to increase the excretion of non-sterol endogenous hydrophobic substances by increasing excretion of fat via the faeces

USPTO Abstract

The subject invention concerns a method to increase the excretion of non-sterol endogenous hydrophobic substances or metabolic derivatives thereof by increasing excretion via the faeces of the hydrophobic substance or metabolic derivative thereof characterisedin that the excretion of fat via the faeces is increased. The purpose of the invention is to prevent or treat conditions associated with the accumulation of non-sterol endogenous hydrophobic substances or metabolic derivatives thereof, such substances being unconjugated bilirubin and protoporphyrin. More particularly, lipstatin, orlistat, tetrahydrolipstatin, polyol fatty acids like olestra, and non-conventional doses of dietary jet are used to treat neonatal jaundice, haemolytic or erythropoietic protoporphyria.