EP1070703A1 — Cyclobutene derivatives

USPTO Abstract

Compounds of formula (I): {in which: R 1 and R 2 each represents a variety of organic groups; R 3 and R 4 each represents hydrogen or a variety of organic groups; A represents a group of formula (A-1):    [in which: R 5 represents hydrogen, hydroxy or alkyl, R 6 represents hydroxy, alkoxy, alkylthio or an amine residue, X and Y each represents oxygen or sulphur, and Z represents a direct single bond between the nitrogen atom shown and the benzene ring shown in formula (I), or an alkylene group], G represents a single bond, alkylene or substituted alkylene; the broken line represents a single or double bond; when the broken line represents a double bond, D represents a carbon atom; and E represents an =N-O- group; when the broken line represents a single bond, D represents a CH group or a nitrogen atom, and E represents an oxygen atom, a sulphur atom, an -NH- group or a -CO- group}; and pharmaceutically acceptable salts, esters or other derivatives thereof have the ability to inhibit an ileal bile transporter and so may be used to treat or prevent hypercholesterolaemia.