EP1020434A4 — 3-amidinoaniline derivatives, activated blood coagulation factor x inhibitors, and intermediates for producing both

USPTO Abstract

3-Amidinoaniline derivatives represented by general formula (I) which have potent and selective activity of inhibiting activated blood coagulation factor X and are useful as activated blood coagulation factor X inhibitors, or pharmacologically acceptable salts thereof and intermediates in producing the same, wherein R represents hydrogen, lower alkyl, lower alkenyl, etc; R1 represents hydrogen, hydroxy, lower alkyl, etc.; Y represents a single bond or oxygen; and R2 represents lower alkyl or a group represented by (a) wherein n is 1 or 2; and T is hydrogen or -C(=NH)-W (wherein W is lower alkyl).