EP0943341A1 — Procedure to prepare granulated compositions that contain erythromycin macrolides and procedure to prepare pharmaceutical compositions that contain said macrolides

USPTO Abstract

Procedure to prepare granulated compositions that contain erythromycin macrolides, useful to prepare pharmaceutical formulations that can be administered orally, of acceptable organoleptic characteristics -flavor and aroma-, characterized because it includes: mixing a protonized resin in particles with an erythromycin macrolide in a solvent means for said compound, during a lapse enough in order to neutralize and to fix, through acid/base exchange, the macrolide, in the granules of the resin; to crush the granules of resin treated this way and if it is necessary, with previous elimination of the solvent; to classify and to select the particles of a predetermined grain measure and to coat the classified particles of substantially neuter aroma and flavor, with a biodegradable coating of programmed liberation of the macrolide from the particles of resin.