EP0943336A1 — Peptide-containing pharmaceutical compositions for oral administration

USPTO Abstract

The present invention provides a pharmaceutical composition for oral administration containing physiologically active peptide such as peptide hormones, opioid peptides, physiologically active proteins, enzyme proteins and the like, with an excellent stability and enhanced absorption via the oral route. More specifically, the invention provides a peptide-containing pharmaceutical composition for oral administration prepared as an enteric coated preparation, wherein an effective dose of physiologically active peptide is dispersed in a physiologically acceptable porous powdery or crystalline polyvalent metal compound carrier with a mean particle diameter of 500 µm or less, i.e., divalent or higher valency metal compound such as aluminum, calcium, magnesium, silicon, iron and zinc compounds. The pharmaceutical composition for oral administration according to the present invention enhances the absorption of physiologically active peptides that normally show poor absorption via the oral route.