EP0940387A1 — Phenylethanolamine compounds useful as beta3 agonist, process for producing the same, and intermediates in the production of the same

USPTO Abstract

The present invention relates to phenylethanolamine compounds represented by general formula [I]:    (where R 1 represents hydrogen or halogen; R 2 represents hydrogen, hydroxy, lower alkoxy, lower alkoxy substituted with one or two lower alkoxycarbonyl or carboxy groups, lower alkoxy substituted with lower alkylaminocarbonyl which may be substituted with lower alkoxy, lower alkoxy substituted with cyclic aminocarbonyl of 4 to 6 carbon atoms, lower alkoxycarbonyl or carboxy; R 3 represents hydrogen, hydroxy, lower alkoxy or lower alkoxy substituted with one or two lower alkoxycarbonyl or carboxy groups; R 2 and R 3 may be bonded to each other to form methylenedioxy substituted with carboxy or lower alkoxycarbonyl; and m and n are 0 or 1), and their pharmacologically acceptable salts, which have a potent β 3 adrenergic stimulating effect and high β 3 adrenergic receptor selectivity, as well as to processes for their production and intermediates in their production.