EP0908182B1 — Preventives or remedies for diseases induced by hypofunction of nitric oxide synthase (nos)

USPTO Abstract

It is an object of the present invention to provide a therapeutic agent for effectively preventing or ameliorating diseases caused by dysfunction of NOS. The present invention provides a pharmaceutical composition for preventing and/or treating diseases associated with dysfunction of NOS, comprising as an effective ingredient, a compound of the formula (I): <CHEM> wherein R<1> and R<2> each represents a hydrogen atom or, taken together with each other, represent a single bond, while R<3> represents -CH(OH)CH(OH)CH3, -CH(OCOCH3)CH(OCOCH3)CH3, -CH3, - CH2OH, or a phenyl group when R<1> and R<2> each represents a hydrogen atom, or -COCH(OH)CH3 when R<1> and R<2> together represent a single bond, or a pharmaceutically acceptable salt thereof.