EP0884310A1 — Quinazolin-4-one ampa antagonists

USPTO Abstract

The present invention relates to novel quinazolin-4-one derivatives of the formula I, wherein A is a benzo or thieno fused aromatic ring; B is phenyl, pyridyl or pyrimidyl; X is N or CH; Y and Z, taken together, i.e. , Y-Z, are either -CH 2 NH- or -NHCH 2 -; R 1 is selected from hydrogen, (C 1 -C 6 )alkyl optionally substituted with from one to three fluorine atoms, cyano, halo, amino, nitro and (C 1 -C 6 )alkoxy optionally substituted with from one to three fluorine atoms; R 2 is halo, cyano, (C 1 -C 6 )alkyl optionally substituted with from one to three fluorine atoms, nitro, amino, (C 1 -C 6 )alkylthio, (C 1 -C 6 )alkoxy optionally substituted with from one to three fluorine atoms, hydroxy, H-C(=O)-, (C 1 -C 6 )alkyl-O-C(=O)- or NH 2 -C(=O)-; R 3 and R 4 are selected, independently, from hydrogen, (C 1 -C 6 )alkyl optionally substituted with from one to three fluorine atoms, halo, cyano, hydroxy (C 1 -C 6 )alkoxy optionally substituted with from one to three fluorine atoms, -C(=O)H, -CH 2 OR 5 and -CH 2 NR 6 R 7 ; pharmaceutical compositions containing such compounds the use of such compounds to treat neurodegenerative, psychotropic, and drug and alcohol induced central and peripheral nervous system disorders.