EP0879820A1 — Benzamide analogues, useful as PARP (ADP-Ribosyltransferase, ADPRT) DNA repair enzyme inhibitors

USPTO Abstract

A range of benzamide analogues consisting of 3-oxybenzamide derivatives are disclosed which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. The compounds disclosed include certain benzoxazole-4-carboxamide compounds and in general they comprise compounds having the general structural formula I or pharmaceutically acceptable salt thereof, characterised in that    Y and X together form a bridge -Y-X- that represents the grouping       where R 5 is H, alkyl or an optionally substituted aralkyl or aryl group.