EP0806418A2 — Novel pyrimidine compound and anti-rotavirus agent

USPTO Abstract

A pyrimidine compound of the formula ÄIÜ <CHEM> wherein R1 is H, C1-C4 lower alkyl, halogen atom, -OH, C1-C4 lower alkoxy, C1-C6 hydroxy(lower)alkoxy or -NH2; R2 is H, -NH2 or -NHCOCH3; R3 is -NR5(CH2)i-CH2OH; R4 is H, halogen atom, -NH2, -CN, -CHO, -CH2OH, -COOH, -CH2NH2, -CONH2 or -CH=N-A wherein A is -OH, C1-C4 lower alkyl or C1-C4 lower alkoxy; R5 is H or C1-C4 lower alkyl; and i is an integer of 1 to 4, and an anti-rotavirus agent comprising, as an active ingredient, a compound of the formula ÄIÜ wherein R3 is a group selected from the following: <CHEM> The novel pyrimidine compound of the present invention and related derivatives thereof have superior anti-rotavirus action and are useful for the prophylaxis and treatment of rotaviral diseases.