EP0795556A1 — 4-Substituted pyrrolopyrimidine compounds as tyrosin kinase inhibitors

USPTO Abstract

Novel 4-substituted 7H-pyrrolo[2,3-d]pyrimidine derivatives, useful as tyrosine kinase inhibitors, encompassed by following formula (I) wherein X is -CH 2 -, -NH-(CH 2 ) n -, -O-(CH 2 ) n - or -S-(CH 2 ) n - in which n is zero or 1; A is a mono- or bicyclic ring chosen from phenyl, pyridine, tetralin, indan, 2-oxindole, quinoline, isoquinoline and indole; R is hydrogen, C 1 -C 4 alkyl or benzyl; each of R 1 and R 2 , independently, is hydrogen, halogen, C 1 -C 4 alkyl, C 1 -C 4 alkoxy, NR 5 R 6 in which each of R 5 and R 6 independently is hydrogen or C 1 -C 4 alkyl, phenyl unsubstituted or substituted by one to three substituents chosen from halogen, trifluoromethyl, C 1 -C 4 alkyl and C 1 -C 4 alkoxy; each of R 3 and R 4 , independently, is hydrogen, C 1 -C 4 alkyl, halogen, hydroxy, C 1 -C 4 alkoxy, C 1 -C 4 alkoxycarbonyl, nitro, cyano or trifluoromethyl; and the pharmaceutically acceptable salts thereof are provided.