EP0732332A1 — Substituted benzothienylpiperazines, their use as medicaments, and processes for their preparation

USPTO Abstract

This invention relates to compounds of the formula I wherein X is hydrogen, halogen, hydroxy, (C 1 -C 6 )alkoxy, amino or trifluoromethyl; and Y is -CN or -NR 1 R 2 ; where l is an integer of 1 or 2; m is an integer of 0, 1 or 2; n is an integer of 2, 3 or 4, except when Y is CN, in which case n can also be 1; R 1 is hydrogen, (C 1 -C 6 )alkyl or (C 1 -C 6 )alkylcarbonyl; R 2 is hydrogen, (C 1 -C 10 )alkylcarbonyl, (C 3 -C 12 )cycloalkylcarbonyl, hydroxy-(C 1 -C 6 )alkylcarbonyl, phenylcarbonyl, thienylcarbonyl or benzothienylcarbonyl; or R 1 and R 2 together with nitrogen atom to which they are attached form the ring where A is C = O or CH 2 ; and B is C = O, CHOH, CH 2 or CH 2 CH 2 ; and Z is hydrogen, halogen, hydroxy, (C 1 -C 6 )alkoxy, amino or trifluoro; and pharmaceutically acceptable acid addition salts thereof, pharmaceutical compositions thereof and their use for the treatment of psychoses.