EP0705832A1 — Serotonergic modulators

USPTO Abstract

A pharmaceutical compound of the formula in which R¹ and R⁷ are each halo, trifluoromethyl, C₁₋₆ alkyl, C₁₋₆ alkoxy, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl, R and R³ are each hydrogen or C₁₋₆ alkyl, R⁴ and R⁵ are each hydrogen, halo, trifluoromethyl, C₁₋₆ alkyl, C₁₋₆ alkoxy, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl, R⁶ is hydrogen, C₁₋₆ alkyl, optionally substituted phenyl, optionally substituted naphthyl, optionally substituted heteroaryl, optionally substituted phenyl-C₁₋₆ alkyl or -CO₂R⁸ where R⁸ is an ester group, m and p are each 0, 1, 2, 3 or 4, n is 1, 2, 3 or 4, Z is where R⁹ and R¹⁰ are each hydrogen, C₁₋₆ alkyl or optionally substituted phenyl-C₁₋₆ alkyl, X is oxygen or sulphur, and Y is where R¹¹ and R¹ are each hydrogen, C₁₋₆ alkyl, trifluoromethyl, optionally substituted phenyl, optionally substituted naphthyl or optionally substituted heteroaryl; and salts and solvates thereof. The compounds of the invention are indicated for use in the treatment of diseases of the central nervous system. They are active in tests that indicate serotonergic modulation.