EP0667150A1 — Venlamafaxine and its analogues for inducing cognition enhancement

USPTO Abstract

This invention provides use of a compound to manufacture a medicament of inducing cognition enhancement. The compound is a 2-(1-hydroxycycloalkyl or 1-hydroxycycloalkenyl)-2-phenylalkylamine derivative having the formula: in which A is a moiety of the formula wherein    the dotted line represents optional unsaturation;    R₁ is hydrogen or alkyl;    R₂ is alkyl;    R₄ is hydrogen, alkyl, formyl, or alkanoyl;    R₅ and R₆ are, independently, hydrogen, hydroxyl, alkyl, alkoxy, alkanoyloxy, cyano, nitro, alkylmercapto, amino, alkylamino, dialkylamino, alkanamido, halo, trifluoromethyl, or taken together, methylene dioxy;    R₇ is hydrogen or alkyl; and    n is 0, 1, 2, 3, or 4; or a pharmaceutically acceptable salt thereof.