EP0632041A1 — New morphine derivatives having improved analgesic and narcotic properties
Assigned to Radboud Universiteit Nijmegen · Expires 1995-01-04 · 31y expired
What this patent protects
Morphine derivatives having the formula wherein: A¹ represents -O-, -S-, -NR⁴- or -CHR⁵- ; A² represents -O-, -S- or -NR⁴- ; R¹ represents C₁-C₄ alkyl, C₁-C₄ alkenyl or cycloalkylmethyl; R² represents H, C₁-C₆ alkyl, C₁-C₆ alkenyl, C₁-C₈ acyl or C₁-C₆ hydroxyalkyl; …
USPTO Abstract
Morphine derivatives having the formula wherein: A¹ represents -O-, -S-, -NR⁴- or -CHR⁵- ; A² represents -O-, -S- or -NR⁴- ; R¹ represents C₁-C₄ alkyl, C₁-C₄ alkenyl or cycloalkylmethyl; R² represents H, C₁-C₆ alkyl, C₁-C₆ alkenyl, C₁-C₈ acyl or C₁-C₆ hydroxyalkyl; one of X¹ and X² represents H and the other one is a group -A³-R³; A³ represents -CH₂-, -CH₂CH₂-, -OCH₂-, -SCH₂-, -NR⁴CH₂-, -CO-, -NR⁴CO-, -SCO-, -SO₂-, -NR⁴SO₂-, -O-, -S- or -NR⁴-; R³ represents an optionally substituted heterocyclic group; R⁴ and R⁵ independently represent H or C₁-C₄ alkyl; whereby the morphinan system may have a further unsaturation, in additon to the benzene ring. These new morphine derivatives have improved analgesic and narcotic properties.
Drugs covered by this patent
- Zyprexa (olanzapine) · Eli Lilly
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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