EP0597107A1 — Lignan analog, production thereof, and hypolipidemic drug

USPTO Abstract

A hypolipidemic drug which has a potent activity of reducing LDL and VLDL cholesterols which are thought to be a risk factor causative of arteriosclerosis among total blood cholesterols and is excellent in the antioxidant activity on LDL; and a compound represented by general formula (I) and a pharmaceutically acceptable salt thereof, wherein R¹ represents optionally substituted lower alkyl, cycloalkyl, cycloalkylated lower alkyl, aryl or aralkyl; R² represents - COOR', lower alkyl or halogenated lower alkyl, or aternatively R¹ and R² form together with the adjacent carbonyl group a cyclohexanone ring represented by formula (II); R³ represents optionally substituted phenyl; and ring A represents an optionally substituted benzene ring or an optionally substituted heterocycle containing either sulfur or oxygen.