EP0545478A1 — Heterocyclic compounds as tachykinin antagonists

USPTO Abstract

Compounds of formula (I): wherein    Q¹ represents a phenyl group substituted by one or more halo; naphthyl; indolyl; benzthiophenyl; benzofuranyl; benzyl; or fluorenyl;    R¹ is H, C₁₋₆alkyl or C₂₋₆alkenyl;    R² is phenyl(C₁₋₄alkyl) optionally substituted in the phenyl ring by one or more groups selected from C₁₋₆alkyl, C₂₋₆alkenyl, C₂₋₆alkynyl, halo, cyano, nitro, trifluoromethyl, SR b , SOR b , SO₂R b , OR b , NR b R c , NR b COR c , NR b COOR c , COOR b or CONR b R c , where R b and R c independently represent H, C₁₋₆alkyl, phenyl or trifluoromethyl; and    Z is O, S, NR⁸ or CR⁹R¹⁰, where R⁸ represents H, C₁₋₆alkyl, phenyl, phenyl(C₁₋₄alkyl), COR¹¹, COOR¹¹, CONR⁹R¹⁰ where R¹¹ is phenyl, phenyl(C₁₋₄alkyl) or C₁₋₆alkyl, and R⁹ and R¹⁰ are each H, C₁₋₆alkyl, phenyl or phenyl(C₁₋₄alkyl); are tachykinin antagonists. They and their compositions are useful in medicine.