EP0543942A1 — Homogeneous assay system
Assigned to F Hoffmann La Roche AG · Expires 1993-06-02 · 33y expired
What this patent protects
A method of detecting a target nucleic acid using labeled oligonucleotides uses the 5 'to 3' nuclease activity of a nucleic acid polymerase to cut a labeled and circularized oligonucleotide of hybridized duplexes, and to release nucleotide fragments labeled for detection. This pr…
USPTO Abstract
A method of detecting a target nucleic acid using labeled oligonucleotides uses the 5 'to 3' nuclease activity of a nucleic acid polymerase to cut a labeled and circularized oligonucleotide of hybridized duplexes, and to release nucleotide fragments labeled for detection. This process is easily integrated into an amplification assay of the polymerase chain reaction.
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