EP0536817A1 — Azabicyclic compounds as tachykinin antagonists

USPTO Abstract

Compounds of formula (I), and salts and prodrugs thereof: wherein    Q is the residue of an optionally substituted azabicyclic ring system;    the dotted line represents an optional double bond;    X represents H, -OH, =O or halo;    R¹ represents H, phenyl or thienyl, which phenyl or thienyl groups may be optionally substituted by halo or trifluoromethyl;    R² represents phenyl, thienyl or benzyl, any of which groups may be optionally substituted by halo or trifluoromethyl; and    R³, R⁴ and R⁵ independently represent H, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, halo, cyano, nitro, trifluoromethyl, trimethylsilyl, -OR a , SR a , SOR a , SO₂R a , -NR a R b , -NR a COR b , -NR a CO₂R b , -CO₂R a or -CONR a R b ; and    R a and R b independently represent H, C₁₋₆ alkyl, phenyl or trifluoromethyl, are tachykinin receptor antagonists. They and compositions thereof are useful in therapy.