EP0528337A1 — New thiazolylbenzofuran derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same

USPTO Abstract

A compound of the formula : wherein    R¹ is lower alkyl optionally substituted with halogen, lower alkylamino or lower alkyl(acyl)amino; cyclo(lower)alkyl; tricycloalkyl; aryl optionally substituted with lower alkoxy; or a heterocyclic group;    R² is hydrogen or halogen, or    R¹ and R² are taken together with the adjacent atoms to form cycloalken ring or an N-containing heterocyclic group optionally substituted with acyl,    R³ is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy,    R⁴ is hydrogen; acyl; cyano; aryl optionally substituted with hydroxy(lower)alkyl, halo(lower)alkyl, cyano(lower)alkyl, heterocyclic(lower)alkyl or acyl; or lower alkyl which may be substituted with substituent(s) selected from the group consisting of halogen, cyano, hydroxy, lower alkylsulfonyloxy, arylsulfonyloxy, acyl, acyl(lower)alkylthio and aryl optionally substituted with halo(lower)alkyl, cyano(lower)alkyl, heterocyclic(lower)alkyl, cyano, acyl, acyl(lower)alkyl, a heterocyclic group or (lower alkylsulfinyl)(lower alkylthio)lower alkenyl;    A is lower alkylene, lower alkenylene or a single bond,    X is a single bond, O or S, and    Y is O or S, provided that A is loweralkylene or lower alkenylene, or       X is O or S when R¹ is lower alkyl or aryl and R² is hydorgen, and pharmaceutically acceptable salts thereof, processes for their preparation and pharmaceutical compositions comprising them.