EP0498361A2 — Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor
Assigned to Merck Sharp and Dohme LLC · Expires 1992-08-12 · 34y expired
What this patent protects
Treatment of hypertension or congestive heart failure with a combination of an angiotensin II antagonist or a renin inhibitor with a neutral endopeptidase inhibitor, pharmaceutical compositions comprising said combinations and kits for administering separate pharmaceutical compos…
USPTO Abstract
Treatment of hypertension or congestive heart failure with a combination of an angiotensin II antagonist or a renin inhibitor with a neutral endopeptidase inhibitor, pharmaceutical compositions comprising said combinations and kits for administering separate pharmaceutical compositions in combination are disclosed, wherein the angiotensin II antagonists include saralasin, sar 1, ile 8 angiotensin II, Dup 753, EXP 6155, EXP 6803 and PD 123319, the renin inhibitors include enalkrein, RO 42-5892, A 65317, CP 80794, ES 1005, ES 8891, SQ 34017, CGP 29287, CGP 38560, SR 43845, U-71038, A 62198, and A 64662, and the neutral endopeptidase inhibitors include N-[N-[1(S)-carboxyl-3-phenylpropyl]-(S)-phenylalanyl]-(S)-isoserine, N-[N-[((1S)-carboxy-2-phenyl)ethyl]-(S)-phenylalanyl]-β-alanine; N-[2(S)-mercaptomethyl-3-(2-methylphenyl)-propionyl]methionine, SQ 28603, UK 69578, SQ 29072, thiorphan, retro-thiorphan and phosphoramidon.
Drugs covered by this patent
Bibliographic data sourced from FDA Orange Book + USPTO public records. Plain-English summary generated by AI grounded in source text. Patent term extensions (PTR, SPC, pediatric) may shift the effective expiry. Not legal advice.
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