EP0496437A2 — Use of specific core material and layers to obtain pharmaceutical formulations stable to discolouration of omeprazole

USPTO Abstract

The use of core material in the form of small beads or tablets containing as the active compound omeprazole together with an alkaline reacting compound, or an alkaline salt of omeprazole optionally together with an alkaline reacting compound, and on said core material one or more inert reacting subcoating layers comprising tablet excipients which are soluble or rapidly disintegrating in water, or polymeric, water soluble, filmforming compounds, optionally containing pH-buffering, alkaline compounds between the alkaline reacting core and an outer layer, which is an enteric coating, in order to obtain an oral pharmaceutical preparation of omeprazole which is stable to discolouration.